Adamax is an advanced nootropic peptide, an adamantane-modified analog of Semax, known for its enhanced neuroprotective and cognitive benefits. It is typically administered via subcutaneous injection in a gradually increasing daily dose, ranging from 300 mcg to 1 mg. The peptide is reconstituted with bacteriostatic water for multiple doses from a single vial.
- Adamax is an improved analog of Semax, designed for greater potency and stability.
- Doses typically range from 300 mcg to 1000 mcg daily, with a gradual increase over the cycle.
- Reconstituted with 3.0 mL of bacteriostatic water, providing a concentration of 3.33 mg/mL.
- Administered once daily via subcutaneous injection.
- Supports cognitive function, neuroprotection, and mood regulation by increasing BDNF.
Reconstitution
Vial strength
10 mg
Bacteriostatic water
3 mL
Concentration
3.33 mg/mL
1 unit = 0.01 mL = 33.3 mcg
- 1Draw 3.0 mL of bacteriostatic water using a sterile syringe.
- 2Carefully inject the water down the inner wall of the Adamax vial to prevent foaming.
- 3Gently swirl or roll the vial until the peptide powder completely dissolves; do not shake vigorously.
- 4Label the reconstituted vial with the date and store it in the refrigerator at 2–8 °C (35.6–46.4 °F), protected from light.
Dosing schedule
| Phase | Dose | On a U-100 syringe |
|---|---|---|
| Weeks 1-2 | 300 µg | 9 units (0.09 mL) |
| Weeks 3-4 | 500 µg | 15 units (0.15 mL) |
| Weeks 5-6 | 750 µg | 23 units (0.23 mL) |
| Weeks 7+ | 1000 µg | 30 units (0.30 mL) |
Protocol detail
| Start | Begin with 300 µg daily for the first two weeks to allow the body to adapt to the peptide's effects. |
|---|---|
| Increase | Raise the dose to 500 µg daily for weeks 3-4, then to 750 µg for weeks 5-6. |
| Maintenance | Continue with 1000 µg daily from week 7 onwards for ongoing nootropic support. |
| Frequency | One subcutaneous injection per day, ideally in the morning to maintain consistency. |
| Cycle Length | An 8-12 week cycle is recommended; it can be extended to 16 weeks with careful monitoring. |
| Off-Cycle | Follow an equal duration off-cycle period (e.g., 8 weeks on, 8 weeks off) to prevent desensitization or tolerance. |
Overview at a glance
| Goal | Support cognitive enhancement, neuroprotection, and neuroplasticity through BDNF upregulation. |
|---|---|
| Schedule | Daily subcutaneous injections for 8–12 weeks (optionally extend to 16 weeks), followed by an equal off-cycle period. |
| Dose Range | 300–1000 µg daily with gradual titration; 500 µg is a common mid-range dose. |
| Reconstitution | 3.0 mL bacteriostatic water per 10 mg vial, creating a concentration of ~3.33 mg/mL for precise unit measurements. |
| Storage | Lyophilized powder stored frozen; reconstituted solution refrigerated and used within 1-2 weeks. Avoid refreezing reconstituted solution. |
How it works
Adamax is derived from Semax, a known ACTH(4–10) analog with significant nootropic properties. It boosts brain-derived neurotrophic factor (BDNF) expression and enhances the sensitivity of TrkB receptors in the hippocampus. This action promotes neuroplasticity, fostering new synaptic connections and ensuring neuronal survival. Adamax influences neurotransmitter systems, including dopamine and serotonin, and activates intracellular signaling, leading to better memory, learning, and resilience to stress. Its unique adamantane modification improves its ability to cross the blood-brain barrier and extends its half-life, making it more effective than standard Semax and reducing dosing frequency.
Reported effects
- Improved learning and memory consolidation
- Enhanced mental clarity and cognitive function
- Neuroprotection against stress and damage
- Modulation of mood, reducing anxiety and stress
- Increased neuroplasticity and synaptic growth
Reported side effects
- Generally well tolerated with no major adverse effects observed in Semax studies
- Mild injection-site reactions (redness, itching, discomfort)
- Limited long-term human data specifically for Adamax
- No significant impact on IGF-1 or metabolic function expected
Storage
Lyophilised (unmixed)
Store lyophilized powder at -20 °C (-4 °F) in dry, dark conditions, in original packaging.
After reconstitution
Refrigerate reconstituted solution at 2–8 °C (35.6–46.4 °F) and use within 1–2 weeks; avoid repeated freeze-thaw cycles and protect from light.
Supplies
| Peptide vials (Adamax, 10 mg each) | 4 vials for 8 weeks, 7 vials for 12 weeks, or 9 vials for 16 weeks (gradual dosing). |
|---|---|
| Insulin Syringes (U-100) | 7 syringes per week (1 per day); consider 30- or 50-unit syringes for initial lower doses. |
| Bacteriostatic Water (10 mL bottles) | 2 bottles for 8 weeks, 3 bottles for 12 weeks, or 3 bottles for 16 weeks (assuming new bottle for each batch of reconstitution). |
| Alcohol Swabs | Two per day (one for vial, one for injection site); approximately 112 for 8 weeks, 168 for 12 weeks, 224 for 16 weeks. |
Important notes
- Always use a new, sterile insulin syringe for each injection and dispose of it in a sharps container.
- Rotate injection sites daily (abdomen, thighs, upper arms) to prevent irritation and lipohypertrophy.
- Inject slowly and steadily, allowing the dose to absorb before withdrawing the needle.
- Keep a record of daily doses, injection sites, and any subjective effects to monitor response.
Frequently asked questions
What makes Adamax different from Semax?
Adamax is an advanced version of Semax, enhanced with an adamantane moiety. This modification significantly improves its ability to cross the blood-brain barrier and increases its stability and potency, leading to more pronounced and prolonged nootropic and neuroprotective effects compared to standard Semax.
How should I store Adamax before and after reconstitution?
Lyophilized (powder) Adamax should be stored frozen at -20 °C (-4 °F) in a dry, dark place. Once reconstituted with bacteriostatic water, the solution should be refrigerated at 2-8 °C (35.6-46.4 °F) and used within 1-2 weeks. Avoid freezing the reconstituted solution or subjecting it to freeze-thaw cycles, as this can degrade the peptide.
What is the recommended injection technique for Adamax?
Adamax is administered via subcutaneous injection. Clean the vial stopper and injection site with alcohol. Draw the prescribed dose into a sterile U-100 insulin syringe, then pinch a fold of skin (abdomen, thigh, or upper arm) and insert the needle at a 45-90 degree angle. Inject slowly, withdraw the needle, and apply gentle pressure. Remember to rotate injection sites daily.
How long should I cycle Adamax, and do I need an off-cycle period?
An Adamax cycle typically lasts 8-12 weeks, with an optional extension to 16 weeks under careful monitoring. It is recommended to follow an off-cycle period of equal duration (e.g., 8 weeks on, 8 weeks off) to help prevent potential tolerance development and maintain the peptide's efficacy over time.
Educational reference only. These figures summarise how Adamax is commonly described in research literature and supplier documentation, including the Adamax listing at peptidesuk4u.co.uk. They are not a prescription, not medical advice, and not a recommendation to self-administer anything.
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