HMG is a gonadotropin containing both FSH and LH activity. In men, it is used to stimulate sperm production, often in conjunction with hCG. This protocol outlines a thrice-weekly subcutaneous dosing regimen.
- Contains both FSH and LH activity (75 IU of each).
- Primarily used in males to stimulate spermatogenesis.
- Typically combined with hCG therapy for best results.
- Requires a 3.0 mL injection volume per dose.
- Minimum 12-week treatment duration.
Reconstitution
Vial strength
0.15 mg
Bacteriostatic water
3 mL
Concentration
0.05 mg/mL
1 unit = 0.01 mL = 0.25 IU
- 1Draw 3.0 mL of bacteriostatic water using a sterile 3 mL syringe.
- 2Slowly inject the water down the inner wall of the HMG vial to prevent foaming.
- 3Gently swirl or roll the vial until the powder completely dissolves; do not shake vigorously.
- 4Label the reconstituted vial with the date and time, then store in the refrigerator at 2-8 °C, shielded from light.
- 5For optimal potency, use the reconstituted solution as soon as possible, or within a few days if refrigerated.
Dosing schedule
| Phase | Dose | On a U-100 syringe |
|---|---|---|
| Weeks 1–12 | 75 IU (0.15 mg) | 3.0 mL (300 units) |
| Weeks 13–16 (optional) | 75 IU (0.15 mg) | 3.0 mL (300 units) |
Protocol detail
| Dose | Inject 75 IU three times weekly (e.g., Monday, Wednesday, Friday). |
|---|---|
| Combination Therapy | Administer HMG in conjunction with hCG (2–3 times weekly) to support testosterone production and maximize sperm production. |
| Cycle Length | A minimum of 12 weeks is recommended, which may be extended to 16 weeks depending on individual response. |
| Route | Subcutaneous injection into areas with fatty tissue, such as the abdomen, thigh, or upper arm. |
| Timing | Maintain consistent injection days each week and rotate injection sites regularly. |
Overview at a glance
| Goal | To stimulate spermatogenesis in men experiencing hypogonadotropic hypogonadism or infertility. |
|---|---|
| Schedule | Three subcutaneous injections per week for a minimum of 12 weeks, with an option to extend to 16 weeks based on response. |
| Dose | 75 IU (0.15 mg) per injection, typically administered alongside hCG therapy. |
| Reconstitution | Reconstitute each 75 IU vial with 3.0 mL of bacteriostatic water, resulting in a concentration of 25 IU/mL. |
| Storage | Unreconstituted HMG is refrigerated. Reconstituted solution should be used promptly or refrigerated and used within a few days. |
How it works
HMG delivers both Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) activity, which are crucial for male reproductive health. In men with certain conditions like hypogonadotropic hypogonadism, FSH is vital for initiating and sustaining spermatogenesis (sperm production). When hCG therapy alone is insufficient to produce adequate sperm, the addition of HMG provides the necessary FSH component to support testicular function and fertility. Clinical studies indicate that this combination significantly improves sperm quality, including motility and concentration, and can increase pregnancy rates for couples undergoing fertility treatments.
Reported effects
- Stimulates sperm production in men with specific types of hypogonadism or infertility.
- Enhances sperm motility, morphology, and concentration when used with hCG.
- Increases pregnancy rates for couples undergoing fertility treatments.
- Supports overall testicular function and hormone regulation.
Reported side effects
- Reactions at the injection site (redness, swelling, mild pain).
- Headache, fatigue, or mood alterations (infrequent).
- Gynecomastia (enlargement of breast tissue) from hormonal effects.
- Rare instances of overstimulation with excessive dosing.
- Allergic reactions (uncommon); discontinue if hypersensitivity occurs.
Storage
Lyophilised (unmixed)
Refrigerate at 2-8 °C (35.6-46.4 °F), protect from light; stable at room temp up to 25 °C (77 °F).
After reconstitution
Refrigerate at 2-8 °C (35.6-46.4 °F); use promptly or within a few days. Protect from light.
Supplies
| Peptide vials (HMG, 75 IU / 0.15 mg each) | Approximately 36 vials for 12 weeks, or 48 vials for 16 weeks (3 per week). |
|---|---|
| Syringes (3 mL) | Approximately 36 syringes for 12 weeks, or 48 syringes for 16 weeks (one per injection). |
| Bacteriostatic Water (30 mL bottles) | Roughly 4 bottles for 12 weeks (108 mL total needed) or 5 bottles for 16 weeks (144 mL total needed). |
| Alcohol Swabs | About 72 swabs for 12 weeks or 96 swabs for 16 weeks (two per injection day). |
Important notes
- HMG therapy often requires simultaneous hCG administration for optimal outcomes in males.
- Always use a new, sterile syringe for each injection and dispose of it properly in a sharps container.
- Rotate injection sites by at least one inch to prevent skin issues like lipohypertrophy.
- The 3.0 mL injection volume may necessitate splitting the dose into multiple smaller injections or using larger syringes.
- Regular monitoring of semen parameters and hormone levels is crucial to assess treatment effectiveness.
- Clinical response typically requires at least 12 weeks, as spermatogenesis development can take 3–6 months.
Frequently asked questions
Why is the HMG dose volume so large (3 mL)?
The HMG vial contains 75 IU of active ingredient. When reconstituted with 3.0 mL of bacteriostatic water, it results in a concentration where the full 75 IU dose requires a 3.0 mL injection. This larger volume is necessary to deliver the intended therapeutic amount.
Can I use smaller syringes like insulin syringes for HMG injections?
Yes, but you will need to split the 3.0 mL dose into three separate 1 mL injections (each containing 25 IU). These smaller injections should be administered at different sites during the same session. Using a single 3 mL syringe is often preferred for convenience.
Why is it recommended to use HMG with hCG?
HMG provides both FSH and LH activity. While hCG primarily stimulates LH effects (testosterone production), HMG supplies the essential FSH activity needed for robust spermatogenesis. Combining them ensures comprehensive support for male fertility and hormone balance.
How long does it take to see results from HMG therapy?
The clinical response to HMG therapy typically requires at least 12 weeks of treatment. Sperm production (spermatogenesis) is a slow process and may take 3 to 6 months to fully develop and show significant improvements in semen parameters.
Educational reference only. These figures summarise how HMG is commonly described in research literature and supplier documentation, including the HMG listing at peptidesuk4u.co.uk. They are not a prescription, not medical advice, and not a recommendation to self-administer anything.
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