AOD-9604 is a synthetic fragment of human growth hormone designed to promote fat loss without the broader growth-promoting effects. It helps break down fat and prevents new fat storage. Dosing typically involves a gradual increase from 300 mcg to 500 mcg daily via subcutaneous injection.
- Synthetic fragment of human growth hormone (Tyr-hGH 177–191).
- Supports lipolysis (fat breakdown) and inhibits lipogenesis (fat storage).
- Does not elevate IGF-1 levels or cause insulin resistance.
- Typically administered once daily via subcutaneous injection.
- Considered to have a placebo-like safety profile in clinical trials.
Reconstitution
Vial strength
5 mg
Bacteriostatic water
3 mL
Concentration
1.67 mg/mL
1 unit = 0.01 mL = 16.67 mcg
- 1Draw 3.0 mL of bacteriostatic water using a sterile syringe.
- 2Carefully inject the water down the inner wall of the AOD-9604 vial, avoiding direct contact with the peptide powder to prevent foaming.
- 3Gently swirl or roll the vial between your palms until the powder is completely dissolved. Do not shake.
- 4Label the reconstituted vial with the date and refrigerate it at 2–8 °C (35.6–46.4 °F), protected from light.
Dosing schedule
| Phase | Dose | On a U-100 syringe |
|---|---|---|
| Weeks 1-4 | 300 mcg | 18 units (0.18 mL) |
| Weeks 5-12 | 500 mcg | 30 units (0.30 mL) |
Protocol detail
| Start | Administer 300 mcg daily for the first 4 weeks, then increase to 500 mcg daily for weeks 5-12 as tolerated. |
|---|---|
| Target | Reach and maintain 500 mcg daily by Week 5 until the end of the cycle. |
| Frequency | Once daily subcutaneous injection. |
| Cycle Length | 8–12 weeks is standard, with an option to extend to 16 weeks. |
| Timing | Often administered in the morning while fasted. Rotate injection sites to prevent irritation. |
Overview at a glance
| Goal | Aid in fat mass reduction and enhance fat oxidation over time. |
|---|---|
| Schedule | Daily subcutaneous injections for 8–12 weeks, with an optional extension to 16 weeks. |
| Dose Range | Beginning at 300 mcg daily, gradually increasing to 500 mcg daily. |
| Reconstitution | 5 mg vial reconstituted with 3.0 mL bacteriostatic water, yielding approximately 1.667 mg/mL. |
| Storage | Lyophilized form stored frozen; reconstituted solution stored refrigerated, avoiding repeated freeze-thaw cycles. |
How it works
AOD-9604 is a modified fragment derived from human growth hormone that specifically targets fat metabolism without inducing general growth effects. It functions by binding to adipose tissue, stimulating the breakdown of stored fats (lipolysis), and inhibiting the formation of new fat cells (lipogenesis). This peptide also upregulates β3-adrenergic receptors in fat tissue, which are often suppressed in obese individuals, thereby enhancing fat-burning pathways. Crucially, unlike full-length hGH, AOD-9604 does not alter IGF-1 levels or impair glucose tolerance, contributing to its favorable safety profile in clinical assessments.
Reported effects
- Supports reduction of fat mass and increases fat oxidation.
- Preferential loss of abdominal fat observed.
- Does not significantly raise IGF-1 levels.
- Has a safety profile comparable to placebo.
- Potential for cartilage repair and bone health benefits (preclinical).
Reported side effects
- Occasional mild injection site reactions (e.g., redness, itching).
Storage
Lyophilised (unmixed)
Store lyophilized powder at -20 °C (-4 °F) in dry, dark conditions; stable for over 1 year.
After reconstitution
After reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 3–4 weeks. Avoid freeze-thaw cycles and protect from light.
Supplies
| Peptide vials (AOD-9604, 5 mg each) | Roughly 5 vials for an 8-week cycle, 8 vials for 12 weeks, or 11 vials for 16 weeks. |
|---|---|
| Insulin Syringes (U-100) | Approximately 7 syringes per week (1 per day); e.g., 56 for 8 weeks or 84 for 12 weeks. |
| Bacteriostatic Water (10 mL bottles) | Use 3.0 mL per vial. For example, 2 bottles for 8 weeks (15 mL needed) or 3 bottles for 12 weeks (24 mL needed). |
| Alcohol Swabs | Approximately 14 swabs per week (2 per day); e.g., 112 for 8 weeks or 168 for 12 weeks. |
Important notes
- Always use new, sterile U-100 insulin syringes (29-31 gauge) and dispose of them in a sharps container.
- Rotate injection sites regularly (abdomen, thighs, upper arms) to minimize local irritation and prevent lipohypertrophy.
- Inject slowly and allow a few seconds before withdrawing the needle.
- A 5 mg vial provides approximately 10 days of dosing at 500 mcg/day or 16–17 days at 300 mcg/day.
- Allow vials to reach room temperature before opening to reduce condensation.
Frequently asked questions
What is the primary difference between AOD-9604 and full-length Human Growth Hormone (hGH)?
AOD-9604 is a specific fragment of hGH that focuses solely on fat metabolism (lipolysis and anti-lipogenesis) without promoting general growth or affecting IGF-1 levels and glucose tolerance, which are common with full-length hGH.
Can AOD-9604 be used long-term?
Typical protocols suggest a cycle length of 8-12 weeks, with an option to extend to 16 weeks. Long-term safety beyond these durations is not extensively documented in standard educational protocols.
How does AOD-9604 contribute to fat loss without affecting muscle or other tissues?
AOD-9604 is designed to specifically target fat cells, promoting their breakdown and inhibiting new fat storage. It achieves this by selectively binding to adipose tissue and upregulating specific receptors involved in fat metabolism, without the systemic growth-promoting effects that might impact other tissues.
What should I do if I miss a dose of AOD-9604?
If a dose is missed, it's generally best to take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not double your dose to make up for a missed one. Consistency is key, but minor deviations typically do not significantly impact the overall protocol.
Educational reference only. These figures summarise how AOD-9604 is commonly described in research literature and supplier documentation, including the AOD-9604 listing at peptidesuk4u.co.uk. They are not a prescription, not medical advice, and not a recommendation to self-administer anything.
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