CJC-1295 NO DAC is a synthetic growth hormone-releasing hormone (GHRH) analog designed to stimulate the body's natural production of growth hormone. It is typically administered via subcutaneous injection in doses ranging from 100-300 mcg daily to support various physiological processes like body composition and recovery.
- Stimulates natural, pulsatile growth hormone secretion.
- Administered once daily via subcutaneous injection.
- Typical cycle length is 8-12 weeks.
- Reconstitute 5 mg vial with 3.0 mL bacteriostatic water.
- Best injected at bedtime to align with natural GH release.
Reconstitution
Vial strength
5 mg
Bacteriostatic water
3 mL
Concentration
1.67 mg/mL
1 unit = 0.01 mL = 16.7 mcg
- 1Draw 3.0 mL of bacteriostatic water using a sterile syringe.
- 2Carefully inject the water into the peptide vial by letting it run down the side, avoiding direct contact with the powder to prevent foaming.
- 3Gently swirl or roll the vial until the peptide is fully dissolved; do not shake.
- 4Label the reconstituted vial with the date and store in the refrigerator at 2–8 °C (35.6–46.4 °F), protected from light.
Dosing schedule
| Phase | Dose | On a U-100 syringe |
|---|---|---|
| Weeks 1–2 | 100 mcg | 6 units (0.06 mL) |
| Weeks 3–4 | 150 mcg | 9 units (0.09 mL) |
| Weeks 5–6 | 200 mcg | 12 units (0.12 mL) |
| Weeks 7–12 | 250–300 mcg | 15–18 units (0.15–0.18 mL) |
Protocol detail
| Start | Begin with 100–150 mcg daily, gradually increasing the dose by about 50 mcg every 1–2 weeks if well tolerated. |
|---|---|
| Target | Aim for a daily dose of 200–300 mcg by weeks 5–12. |
| Frequency | Administer once per day via subcutaneous injection, ideally before bedtime. |
| Cycle Length | Typically 8–12 weeks, with an option to extend to 16 weeks. |
| Timing | Inject at bedtime to synchronize with the body's natural nocturnal growth hormone pulses. Remember to rotate injection sites. |
Overview at a glance
| Goal | To induce pulsatile GH release and raise IGF‑1 levels, supporting improved body composition, faster recovery, and metabolic health. |
|---|---|
| Schedule | Daily subcutaneous injections over an 8–12 week period (can be extended up to 16 weeks). |
| Dose Range | A gradual increase from 100–300 mcg daily. |
| Reconstitution | Use 3.0 mL of bacteriostatic water per 5 mg vial, yielding approximately 1.67 mg/mL for precise unit measurements. |
| Storage | Lyophilized vials can be refrigerated or frozen. Reconstituted solution must be refrigerated, avoiding repeated freezing and thawing. |
How it works
CJC-1295 NO DAC, also known as Modified GRF 1–29, is an engineered GHRH analog that enhances its stability against enzymatic breakdown through specific amino acid substitutions. It functions by binding to GHRH receptors on the pituitary gland, which in turn stimulates the production and release of the body's own growth hormone in a pulsatile manner. Unlike direct GH administration, this mechanism maintains the body's natural feedback loops, allowing for physiological GH secretion rhythms. Its short half-life ensures discrete, natural-mimicking GH pulses.
Reported effects
- Stimulates pulsatile growth hormone release
- Elevates IGF-1 levels
- Improves body composition (lean mass, reduced fat)
- Enhances recovery
- Improves sleep quality
- Boosts energy levels
Reported side effects
- Injection-site reactions (redness, swelling)
- Transient flushing
- Headache
Storage
Lyophilised (unmixed)
Refrigerate at 2–8 °C (35.6–46.4 °F); for extended storage, freeze at ≤−20 °C (≤−4 °F).
After reconstitution
Refrigerate at 2–8 °C (35.6–46.4 °F) and use within 1–2 weeks; avoid repeated freeze–thaw cycles.
Supplies
| Peptide vials | Approximately 2-4 vials needed for an 8-16 week protocol (5 mg each). |
|---|---|
| Insulin Syringes (U-100) | Roughly 56-112 syringes for an 8-16 week protocol (1 per day). |
| Bacteriostatic Water | Minimum 1 x 10 mL bottle for reconstituting up to 3 vials. |
| Alcohol Swabs | At least 200 swabs for an 8-12 week protocol (2 per day). |
Important notes
- Always use new, sterile insulin syringes and dispose of them in a sharps container.
- Rotate injection sites (e.g., abdomen, thighs, upper arms) to prevent local irritation.
- Inject slowly and wait a few seconds before removing the needle.
- Keep a record of your daily dose and injection site rotation.
- Administer on an empty stomach (fasted for at least 2 hours) to maximize growth hormone response.
Frequently asked questions
What is the key difference between CJC-1295 NO DAC and exogenous growth hormone?
CJC-1295 NO DAC stimulates your body's own pituitary gland to produce growth hormone in a natural, pulsatile rhythm. Exogenous growth hormone, conversely, directly introduces external GH, which can suppress natural production and disrupt the body's feedback mechanisms.
How crucial is injecting CJC-1295 NO DAC at bedtime?
Injecting at bedtime is recommended because it aligns with your body's natural nocturnal growth hormone release patterns. This timing helps to optimize the peptide's effectiveness by working in synergy with your physiological cycles.
Can I use plain sterile water instead of bacteriostatic water for reconstitution?
No, it is highly recommended to use bacteriostatic water for reconstitution. Bacteriostatic water contains a preservative that inhibits bacterial growth, allowing the reconstituted solution to be safely stored in the refrigerator for the recommended duration (1-2 weeks). Plain sterile water lacks this preservative and significantly shortens the shelf life of the reconstituted peptide.
If I miss a dose, should I double the next one?
No, it is generally not advisable to double a dose if you miss one. Simply resume your regular dosing schedule the next day. Consistency is more important, and doubling doses can potentially increase the risk of side effects without proportional benefit.
Educational reference only. These figures summarise how CJC-1295 NO DAC is commonly described in research literature and supplier documentation, including the CJC-1295 NO DAC listing at peptidesuk4u.co.uk. They are not a prescription, not medical advice, and not a recommendation to self-administer anything.
Related protocols
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Long-acting GHRH analog for sustained growth hormone release.
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Sermorelin (10 mg Vial)
Stimulates natural growth hormone, supports IGF-1 levels.